The Living History Museum’s collection covers the entire history of UMSON, from its founding in 1889 to the present day. On display in the museum are several hundred diverse artifacts ranging from nursing uniforms to medical instruments nurses used on their daily rounds. Highlights include early instructional textbooks, contents from a 1910 private duty nurse’s traveling bag, and a model of Mary V. Neal's original rocking hammock.
The museum's archival collection consists of an extensive holding of documents and photographs from UMSON’s history and administration. Among the holdings are war-time correspondences from nurses serving in the military, late 19th century photographs of University Hospital, documents regarding the legal battle of the School’s first African-American student to gain admittance, papers from the Alumni Association's founding in the 1890’s, and class photographs.