Susan Dorsey, PhD, RN, FAAN
Associate Professor, OSAH
Associate Dean for Research
Address:
727A
Phone Number:
410-706-7250
Fax Number:
410-706-5427
Education:
- Post-doctoral Training; Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland
- PhD, University of Maryland, Baltimore, Baltimore, Maryland
- MS, University of Maryland, Baltimore, Baltimore, Maryland
- BS, West Virginia Wesleyan College, Buckhannon, West Virginia
Research:
| R01NR012686 | Dorsey and Sweatt (MPI) |
| NIH/NINR | 09/28/2010-07/31/2015 |
| $3,695,847 | |
| Epigenetic modifications of BDNF and trkB genes underlie pain plasticity | |
| The purpose of this study is to examine the role for epigenetic modification of BDNF and trkB in the persistence of chronic pain/central sensitization. Aim 3 will examine the epigenome. | |
| 1P30NR011396 | Dorsey (PI) |
| NIH/NINR | 08/07/2009-05/31/2014 |
| $2,400,000 | |
| UM Center for Pain Studies | |
| The goal of the Center is to facilitate translational and interdisciplinary cancer treatment-related pain research on the UM Campus. | |
| 1RC2NR011968 | Dorsey/Ward (MPI) |
| NIH/NINR | 09/25/2009-07/31/2012 (NCE) |
| $2,900,000 | |
| TrkB.T1 as a Genetic Disease Modifier of Muscular Dystrophy | |
| The goal for this study is to understand how genetic regulation of trkB.T1 participates in muscle weakness and fatigue in muscular dystrophy. | |
| 1P30NR011396-02S1 | Dorsey (PI) |
| NIH/NCRR | 08/16/2010-06/30/2012 |
| $1,200,000 | |
| UM Center for Pain Studies—Translational Phenotyping Core | |
| The purpose of this study is to create clinical and pre-clinical testing suites within the School of Nursing to expand our phenotyping of pain to include the co-morbidities depression, anxiety, stress, and others. | |
| 1R01NR010207 | Dorsey (PI) |
| NIH/NINR | 06/18/2007-03/31/2012 |
| $1,856,250 | |
| BDNF Signal Strength Modulates NRTI-induced Allodynia in Mouse | |
| The goal of this study is to determine whether BDNF-mediated trkB signaling participates in the development and persistence of chronic HIV treatment-related pain. In addition, we are examining whether exercise (voluntary wheel running) can improve nocifensive behaviors. | |
My laboratory focuses on the identification of cellular and molecular mechanisms of chronic pain so that new therapeutic targets can be identified to improve or ameliorate chronic pain. My most recent project, supported by funding from the 2009 American Recovery and Reinvestment Act, addresses molecular signaling and transcriptional alterations associated with neuromuscular dysfunction in muscular dystrophy.
Recent Publications:
- Mei Y., Liao J., Shen J., Yu L., Liu B., Liu L., Li R., Ji L., Dorsey S.G., Jiang Z., Katz R.L., Wang J-Y, & Jiang F. (2011). Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis. Oncogene, Oct 10 [Epub ahead of print].
- Dorsey S.G., Lovering R.M., Renn C.L., Leitch C.C., Liu X. et al (2011). Genetic deletion of trkB.T1 increases neuromuscular function. Am J Physiol Cell Physiol, Aug 31 [Epub ahead of print].
- Renn C.L., Leitch C., Lessans S., Rhee P., McGuire W., Smith B., Traub R., & Dorsey S.G. (2011). Brain-derived neurotrophic factor modulates antiretroviral-induced mechanical allodynia in the mouse. Journal of Neuroscience Research, Jun 6 [Epub ahead of print].
- Ayala V.I., Teijaro J.R., Farber D.L., Dorsey S.G., & Carbonetti N.H. (2011). Bordetella pertussis infection exacerbates influenza virus through pertussis toxin activity. PLoS ONE, Apr 20;6(4):e19016.
- Renn C.L., Carozzi V.A., Rhee P., Gallop D., Dorsey S.G., & Cavaletti G. (2011). Multimodal assessment of painful peripheral neuropathy induced by chronic oxaliplatin-based chemotherapy in mice. Molecular Pain Apr 26;7:29.
- Resnick B., Galik E., Dorsey S.G., Scheve A., & Gutkin S. (2011). Reliability and validity testing of the Physical Resilience Measures. Gerontologist, March 14 [Epub ahead of print].
Primary Teaching Areas:
Bioinformatics, Cancer Pain, Pain and Signaling Mechanisms, Theory and Conceptualization of Nursing Science, Microarray Technology and Analysis
Academic & Professional Activities:
- 2010-Present: Director, Developing Program in Cancer Pain, University of Maryland Greenebaum Cancer Center
- March 2011: Mail Grant Reviewer, USAMRMC and the American Institute of Biological Sciences
- June 2010-June 2014: Permanent Member Nursing and Related Clinical Science (NRCS-B) Study Section, National Institutes of Health Center for Scientific Review
- 2008-2012: Member, American Cancer Society Institutional Review Group Study Section
- 2011-Present: Member, Cancer Biology T32 Steering Committee
- 2010 – Present: Member, Research Council, Greenebaum Cancer Center, School of Medicine
- 2008-Present: Faculty Mentor, R25 DE019428 (pending, Gordon PI). A summer program in research environments (ASPIRE)
- 2007-Present: Faculty Mentor, University of Maryland Post-Doc Network
- 2010-2012: Member, University of Maryland School of Nursing Appointment, Promotion and Tenure (APT) Committee
- 2004-Present: Member, University of Maryland School of Nursing Research Advisory Council
Reviewer for the following journals:
- Spinal Cord, 2011-present
- Journal of Neuroscience, 2010-present
- Experimental Neurology, 2009-present
- Supportive Care in Cancer, 2009-present
- Research in Nursing and Health, 2008-present
- Biological Research in Nursing, 2009-present
- Cancer Nursing, 2009-present
- Brain Research, 2008-present
- Neurobiology of Disease 2007-present
- Journal of Neuroscience Research 2004-present
- Lung Cancer, 2009-present
